The causes of sex-related disparities in cancer risk may be better understood, which will help with prevention and therapy.
To investigate, Sarah S Jackson, PhD, of the National Cancer Institute, part of the National Institutes of Health, and her colleagues.
Examined the differences in cancer risk among 171 274 male and 122 826 female persons aged 50 to 71 years for each of the 21 cancer cases.
From 1995 to 2011, they took part in the NIH-AARP Diet and Health research.
In that time, there were 8,742 more cases of new cancer in women than in men (17,951).
Risks were 1.3–10.8 times higher in males than in women in various anatomic sites, with the exception of thyroid and gallbladder cancers, where incidence was lower in men than in women.
Men's risks for bladder cancer, oesophageal cancer, larynx cancer, and stomach cancer have all grown significantly.
Even after accounting for a wide range of risk behaviors and carcinogenic exposures, men still had a higher risk of developing most cancers.
The risk of cancer in males versus women differs significantly due to physiological, immunological, genetic, and other factors.